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Accueil > Équipes > OPTique et IMAgeries > Physics and imaging for life science > Structural and functional biomedical imaging

Ultrastructural analysis of mineralized tissues

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Identifying sub-microscopic scale structural markers of bone diseases is a key step in deciphering their functional (e.g. biomechanical) mechanisms. Based on the developments in synchrotron X-ray bioimaging (qsSAXSI, collab. ESRF), electron diffraction microscopy (TEM-ACOM, collab. SIMAP) and focused ion beams (FIB-SEM, collab. McMaster Univ., Canada), we now aim to develop new correlative imaging approaches to analyze the mineral nanocrystals in human and pathological bone, targeting rare bone diseases associated with hyper-mineralization (e.g. Oxalosis, collab. INSERM Lyon) and ectopic mineralization of soft tissues (Gout, collab. INSERM Lariboisière). The role of the cellular network in such diseases needs to be clarified, for which we are developing new analytical approaches based on machine-learning and graph theory (collab. LARIS, GIPSA) of optical measurements. All these developments aim to : 1) understand the role of bone modifications in the early stages of arthritis (collab. INSERM Lariboisière) and 2) assess the impact of cellular porosity in the surgical treatment of carries (collab. Centrale-Supelec, INSERM Montrouge).