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Home > Teams > OPTics and IMAging > Physics and imaging for life science > Structural and functional biomedical imaging

Structural and functional biomedical imaging

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Technical support: P. Moreau

This section is specific to ex-vivo tissue quantitative imaging in a biomedical context (i.e. on living tissues or biopsies) focused on two areas of expertise: brain and mineralized tissues.

1 Functional neuron imaging - Marco CANEPARI

2 Ultrastructural analysis of mineralized tissues - Aurélien GOURRIER

1 Functional neuron imaging

Native-neuron imaging from brain slices is an area of expertise of the team, who studies physiological excitability relying on the synergistic activity of several Na+, K+ and Ca2+ channel types. Using an innovative approach integrating imaging methods and computational approaches, we recently pioneered a strategy to deduce the parallel activity of different types of ion channels in cerebellar Purkinje neurons. Our final goal is to investigate neuronal channelopathies underlying several forms of brain disorders such as epilepsy, autism or ataxia.

Functional neuron imaging strategy
Functional neuron imaging strategy.

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2 Ultrastructural analysis of mineralized tissues

The biomedical analysis of bone and tooth bares a high level of complexity owing to the hiearchical structure of those organs, their organic/mineral composite nature and their nanoscale ultrastructure. Their biomechanical properties directly depend on those parameters which can be strongly affected in pathological condition. Because of the extent in dimensional scales to consider from the organ level to this of collagen microfibrils and mineral nanocristals, biomedical analysis require coupling many modalities and correlative imaging is mandatory.

Our team has a unique expertise for mineralized tissues studies, associating linear and non-linear optical imaging methods, electron microscopy and synchrotron X-ray imaging in particular. To this end, we developped the necessary skills to cover the full experimental chain, from sample preparation to biomedical structural analysis including instrumental and software development.

Beyond our unique knowledge in bioimaging, we are currently expanding the fundamental theoretical framework based on physics of complex systems to better exploit the biological and structural information.

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