Home > Research > Talks & Conferences > Talks Given at LIPhy
published on , updated on
These talks are given by invited speakers at LIPhy. The intended audience is the whole LIPhy. A large general introduction intended for non-specialist is usually provided.
Typical talk duration is around one hour and includes about 15 mn of questions. The talks are scheduled usually every monday at 2PM. The place is at the conference room, second floor. Access to the lab can be obtained through the secretaries.
Résumé : In the last decades, physics-based simulation in Computer Graphics has become instrumental in capturing fascinating mechanical phenomena such as cloth folding, ribbon coiling, plant growth, granular flowing, or hair entangling. Complex simulations not only enrich the visual appearance of animations in feature films, but also give the hope in the near future to quickly prototype challenging systems involving post-buckling or collective behaviors, such as virtual garment and hairstyle try-on systems. In soft matter physics, simulation is also on its ways to becoming a fundamental tool for improving our understanding of physical phenomena unexplored so far, and for designing new materials with controlled properties.
In this talk I will show that although building a simulator that is both predictive and scalable remains an open challenge, advances towards this goal can be made possible thanks to a pluridisciplinary modeling approach combining skills across Mechanics and Physics, Applied Mathematics, and Computer Science.
Lieu : LIPHY, conference room - 140 Avenue de la Physique 38402 Saint Martin d’Hères
Résumé : Gold nanoparticles (GNP) possess exceptional physico-chemical properties, which allow their use in many biomedical fields, such as drug delivery and photothermal therapy. Generally, two major morphologies are used for the biomedical applications: isotropic-shapes as gold nanospheres (GNS) and anisotropic-shapes (GNF), also known as gold nanoflowers, nanostars or nano-urchins. The main advantage of GNF is the presence of different surface energies due to different corners or edges leading to a strong enhancement of the electromagnetic field and temperature upon irradiation. Moreover, GNF compared to GNS offer a greater surface to volume area for functionalization especially in the case of nanovectors synthesis. In the first part of this talk, I will show you a multiparametric study on cellular uptake of GNS and GNF on endothelial cells depending on GNP size, shape, surface chemistry and concentration. Recently, A lot of efforts have been made to optimize the GNP properties for successful tumor targeting, where criteria, such as shape, size, charge, concentration, and route of administration have been intensely discussed to enhance their tumor targeting efficiency. For biomedical applications, GNP have to be ultimately administered to humans and brought into contact with the biological fluids such as plasma and blood. In these fluids GNP encounter a large variety of dissolved biomolecules including proteins. Within few minutes, a protein layer, known as “protein corona,” forms around GNP and changes their size, charge and surface chemistry. To understand this interaction, the second part of this talk will point a recent technique called scattering correlation spectroscopy (SCS) to measure protein adsorption on GNP surface. As fluorescence correlation spectroscopy, the SCS correlation curve is directly related to the hydrodynamic radius of nanoparticles, to their diffusion coefficient, concentration and shape. The measurement of several parameters such as the number of proteins binding to one GNP, the binding affinity and the cooperativeness of binding for three different plasma proteins on the GNP surface will be shown for both GNS and GNF.
Lieu : LIPHY, conference room - 140 Avenue de la Physique 38402 Saint Martin d’Hères
Résumé :
Lieu : LIPHY, conference room - 140 Avenue de la Physique 38402 Saint Martin d’Hères
Résumé :
Lieu : LIPHY, conference room - 140 Avenue de la Physique 38402 Saint Martin d’Hères
