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Accueil > Coin des étudiants > Offres de Post Doc

SELF - SUSTAINED VELOCITY WAVES AND PATTERN EMERGENCE IN MODEL TISSUES

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Supra-cellular organization is crucial to establish and maintain the structure, function and homeostasis of biological tissues. The reaction-diffusion framework justifies the emergence of morphogenetic patterns from an initially uniform distribution of biochemical molecules controlling cell fate. However, an increasing number of recent studies indicate that cell proliferation and differentiation are also impacted by the dynamic reciprocity between cell mechanical activity and the physical properties of their microenvironment. Several recent works reported that wave-like patterns of the velocity spontaneously appear in colonies of epithelial cells. Those supra-cellular waves appear in spreading epithelial sheets, and become stationary in confined geometries where cell migration is limited to internal rearrangements. Strikingly, supra-cellular waves are characterized by precise wavelength and period.

In this project, we will investigate whether supra-cellular waves induce a spontaneous transcriptomic divergence between the cells situated in the wave nodes and those located in the antinodes of the standing wave.

Activities

The post-doc will :

  • investigate the biophysical nature of supra-cellular waves and their resilience (collaboration with the theoreticians at Laboratoire Interdisciplinaire de Physique).
  • (collaboration with the team "Mechanotransduction and Nuclear functions" at the Institute for Advanced Biosciences)

Skills

The post-doc candidate should have a background and training in biophysics. Experience in data analysis, simulation and cell culture would be appreciated.

Application

For additional information and applications : https://bit.ly/3iLXqu9
MicroTiss team : https://www-liphy.univ-grenoble-alpes.fr/Microtiss-1245

Offre Post Doc