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Accueil > Équipes > OPTique et IMAgeries > Physics and imaging for life science > In vivo photoacoustic imaging

Photoacoustic imaging of the brain

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As an expected ouput of the ERC Coherence project, we want to exploit the 3D acoustic-(super)resolution photoacoustic imager and the minimally-invasive optical resolution photoacoustic microendoscope for imaging the brain of live rodent. The 3D acoustic-resolution imager will be used to monitor the vascularization of the brain of an immobilized animal, and we will seek to validate in vivo the resolution enhancement for blood vessels imaging, currently only demonstrated with microfluidic test phantoms. For the endoscopic approach, a key milestone will be to demonstrate in vivo the possibility to image through a flexible multimode fiber attached to the freely moving rodent’s head. The fact that the fiber will be moving with the animal requires that imaging can be performed without a prior calibration, as proposed in the Wave manipulation section.