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A minimalistic tissue model to study morphogenesis

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Morphogenesis involves finely regulated changes in tissue properties such as stiffness and motility. Central to tissue dynamics is the capacity of cells to stabilize or, on the contrary, remodel cell-cell contacts, thus respectively opposing or favouring cell movements and tissue reorganization and ultimately stability. T0-T1 transition is known as a basic mechanism for cell-cell rearrangement in epithelium organisation. Such transition is a key feature of proper embryo morphogenesis. In this internship we aim at studying this fundamental transition following a bottom up approach.