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Home > Personal pages > Aurélien Gourrier

Aurélien Gourrier

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CNRS Research Scientist (section 05)

My research consists in developing new imaging modalities, instruments and analytical tools for biological materials and tissues studies. My main expertise is in quantitative synchrotron X-ray micro-imaging (qsSAXSI) methods using scattering contrast, with a recent opening towards non-linear and fluorescence optical microscopies.

As a physicist and materials scientist, my goal is to understand fundamental structure-function relationships in biominerals and mineralized tissues in a broad sense, while also addressing applied questions in bone and dental studies, either in a biomedical or an archaeological context.

Current projects are directed to the development and application of several non-conventional imaging modalities:

  • synchrotron quantitative scanning X-ray scattering imaging (qsSAXSI) allows mapping nanoscale structural characteristics of histological sections of bone biopsies. This work is done in close collaboration with several synchrotron sources, including the ESRF, SLS and BESSY II.
  • transmission electron microscopy (TEM) with diffraction contrast (ACOM-TEM) adds crystallographic information to the observation of mineral nanoparticles in TEM images. In collaboration with E. Rauch and M. Véron of the SIMAP lab, Grenoble.
  • scanning electron microscopy coupled with a focused ion beam (FIB-SEM) is a 3D ultrastructural imaging method with electron microscopy resolution enabling in-depth analysis of the collagen fibrillar organisation and the cellular porosity network. This is a collaboration with K. Grandfield, from McMaster University, Canada.
  • confocal and two-photon fluorescence microscopy and third harmonic generation (THG) imaging enables visualizing the cellular porosity networks in bone and tooth dentin and second harmonic generation microscopy (SHG) completes this panel for collagen ultrastructure studies. Collaboration with D. Débarre of LIPhy, E. Beaurepaire and M.C. Schanne-Klein from the LOB in Palaiseau.

For more details, please check Ultrastructural Imaging of Mineralized Tissues, Imaging Systems or my ResearchGate or LinkedIn profiles.

Phone: +33 (0)4 76 51 47 29