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5 January 2021

Optical measurement of sodium currents in the axon initial segment

The action potential is the fundamental signal of neuronal cells. In mammalian neurons, this signal is generated in the initial segment of the axon by a fast sodium current mediated by voltage-gated sodium channels. Luiza Filipis and Marco Canepari have developed a unique method allowing the measurement of the sodium current in the axon initial segment during the action potential generation. This novel technique opens the gate to the full understanding of neuronal excitation and to the investigation of genetic diseases caused by neuronal excitability dysfunction.

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26 October 2020

Quantitative analysis of hidden particles diffusing behind a scattering layer using speckle correlation

Observing objects hidden behind scattering layers is a problem of general interest for biomedical applications, or in aerial, terrestrial and naval transport control and security. In optics, an opaque layer is such that each source point of the object of interest gives rise to a speckle figure, which spreads out over the entire field of view, making the source points non-localizable. We have shown, theoretically and experimentally, that it is possible to measure the diffusion coefficient of micrometric fluorescent beads hidden behind a totally scattering layer.

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21 October 2020

Plasma FIB-SEM, a new tool for nanoscale studies of bone tissue.

Visualizing bone tissue at the nanoscale could provide new cues to better better understand diseases such as osteoporosis and arthritis. It is precisely at that scale that the most fundamental mechanisms take place, which ultimately determine the mechanical properties of bone (elasticity, fragility, toughness) and calcium homeostasis, crucial for numerous physiological processes.

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15 September 2020

White cells use paddling to move

Leukocytes have a ubiquitous capacity to migrate on or in solid matrices and with or without adhesion, which is instrumental to fight infections. The precise mechanisms sustaining migration remain, however, arguable. It is for instance widely accepted that leukocytes cannot crawl on two-dimensional substrates without adhesion. In contrast, we showed that human lymphocytes swim on nonadherent two-dimensional substrates and in suspension.

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14 May 2020

2020 Publication Award of JOR

Le journal of Rheology a décerné son prix 2020 "Publication award" à Abhinendra Singh, Romain Mari, Morton M. Denn & Jeffrey F. Morris pour leur travail sur les suspensions denses et frictionnelles.

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To be noted

Ecole Thématique Mécabio

october 2020 @ Lus-La-Croix-Haute

Active Complex Matter 2020

1-11 sept. 2020 @ Cargese (Corsica)

PhD defenses

this automn @ LIPhy

Invited talks

to come @ LIPhy