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20 June 2022

Mechanisms of cancer cell migration

The migration of cells in 3D media is a complex process and plays a key role in the development of cancers. During metastasis, cancer cells develop a strategy and a mode of migration adapted to their environment to invade other tissues.
In this study, we analyzed the migration of cancer cells with different metastatic potentials in various collagen matrices. The detailed analysis of cell movements enhanced the fact that cancer cells were also able to exhibit different phenotypes according to their metastatic potential.

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19 May 2022

Correlating radio signals with light

Researchers have devised an optical architecture to calculate the correlation of radio signals in an analogue manner. This operation would make it possible, for example, to locate radio transmitters with precision, or to improve the performance of optical interferometry in astronomy.

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9 May 2022

Combining Fluorescence Fluctuations and Photobleaching to Quantify Surface Density

Although Fluorescence Fluctuation Spectroscopy (FFS) are well-known techniques to assess number densities or concentrations of molecules, they fail to provide quantitative results when the species of interest are not evenly labeled. We proposed to combine this kind of methods with photobleaching and theoretically demonstrated that the brightness (as measured by FFS) always decay linearly.

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24 January 2022

Controlling ion channels activity using photoactivatable toxins

Photoactivatable toxins targeting ion channels, derived from animal venoms, have the potential to control the activity of excitable cells with high spatiotemporal precision. An international consortium including researchers from the LIPhy developed a new technology to cage these peptides, enabling precise spatiotemporal control of neuronal ion channels associated with excitability. This technology opens the gate for novel opportunities in translational research and light-guided therapeutic interventions.

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19 January 2022

Relating rheology to microstructure dynamics in dense suspensions of soft particles

Dense suspensions of soft particles possess relatively complex rheological properties, such as the existence of a threshold stress to flow. A new statistical physics approach allows to obtain a tensor constitutive model from the dynamics of the soft particles of the suspension, and thus to link the rheology to the anisotropy of the microstructure.

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