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Home > StagesPhysique du Vivant

StagesPhysique du Vivant

Articles with keyword "Physique du Vivant"

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Coarse-Grained Modeling of the compaction of bacterial DNA

The volume occupied by unconstrained bacterial DNA in physiological saline solutions exceeds 1000 times the volume of a cell. Still, DNA is confined to a well defined region of the cell called (...)

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Blood aggregate detection in micro vascularization by photo-acoustic imaging with optical detection

Blood is a complex fluid whose composition and physical characteristics tell us about a patient’s health. The rheology of blood can be modified by the phenomenon of aggregation of red blood cells (...)

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Characterising Active Substrates to Probe Mechanotransduction

Adherent cells can sense their physical environment (forces, rigidity, shape) and react to external mechanical stimuli. The translation of a mechanical signal into a biochemical cue (...)

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Endothelial cell mechanics using AFM

Cancer is a leading cause of death worldwide. One of the cancer main features is the rapid proliferation of abnormal cells and their invasion into vital organs (metastasis). In order to invade other tissus, cancer cells migrate through the endothelium.

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Evanescent field patterning for optogenetic activation of live cells

About 10 years ago a Nobel Prize was awarded to the invention of fluorescent proteins. Genetically encoded fluorescent molecules opened the route for a previously unimaginable amount of (...)

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Exploration of GTPases activity by biosensors in controlled microenvironment

Understanding how adhesion sites sense varied external cues to modulate downstream signaling networks and cell–ECM force transmission is critical to elucidate the sensory mechanisms underlying invasion and tissue architecture.

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Forces, shape and structure of living cells

Living cells come in a wealth of different shapes depending on their esurroundings. The organisation of their polymeric skeleton reflects this diversity. Using rheology approaches, we seek (...)

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Imaging bacterial adhesion forces

The goal of this project is to decipher the mechanical aspects of bacterial adhesion, in order to understand the relation between the mechanical environment of bacteria and their virulence. (...)

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Microtubule lattice dynamics

Microtubules are omnipresent tube-like polymeric structures in living cells. They serve as mechanical scaffold for cilia, flagella or axons and as intracelluar transport tracks. Throughout their (...)

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Migration of living cells: modelling and numerical simulations

The polymer skeleton of cells can deform using the biochemical energy of ATP. A rheological model has enabled us to describe the link between forces and deformations. By finite element (...)

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